Presentation Profile
NO2 Sterilization Optimization with Redundant Filter Photometer Process Monitoring
Currently Scheduled: 10/15/2024 - 2:05 PM - 2:25 PM
Room: Daffodil
Main Author
Chuck DeCarlo - Process Insights
- Ryan Lerud - Process Insights
Abstract:
With the increasing regulatory and environmental challenges for ethylene oxide, NO2 gas sterilization is considered a leading alternative method for many medical devices. In situ measurement of critical microbicidal process parameters is needed, including the measurement of humidity and sterilant concentration. For this measurement a filter photometer with two discrete vapor probes has been installed at two locations in the gas recirculation conduit of the commercial NO₂ sterilization chambers. Each probe measures the NO₂concentration along with the water content in the process stream. The first probe monitors the NO2 sterilant and humidity after injection, and the second probe provides confirmation of the measurement. Providing redundant measurement of these critical parameters provides objective proof for the attainment of target concentrations and enables parametric release of the processed sterilization load.
