Presentation Profile
A RPLC Method to Quantify NIAS using Large Volume Injection of Strong Sample Solvents
Currently Scheduled: 10/15/2024 - 1:20 PM
Room: South Lobby
Main Author
Deborah Phelps - Dow Chemical
- Shayne Green - Dow Chemical
- Victor Poroj - Dow Chemical
- Matthias Pursch - Dow Chemical
- Peilin Yang - Dow Chemical
- Jingchun Yang - Dow Chemical
- Hannes Graf - Agilent Technologies
- Thomas Ortmann - Agilent Technologies
- Edgar Naegele - Agilent Technologies
Abstract:
The growth in use of post-consumer recycled (PCR) plastics adds to the need for low-level quantitative analyses of non-intentionally added substances (NIAS). Strong solvents are often needed for sample and standard preparations when analyzing different matrixes by liquid chromatography. The direct injection of a strong solvent in RPLC often requires low injection volume to avoid peak broadening and breakthrough in the void area of the chromatogram. In many sample preparations the strong solvent is diluted or evaporated to allow for higher injection volumes. A new method utilizes an advanced technology, called feed injection, which allows for higher volume injection of a strong solvent. Injection of a large volume of a strong solvent in combination with a highly sensitive diode array detector (DAD) provides low limits of detection. This technology will reduce sample preparation time, while allowing for better sensitivity to meet new regulations for substances of concern (SoCs) in PCR.
