Presentation Profile
True Plug-and-Play Chromatography
Currently Scheduled: 1/18/2018 - 11:40 AM - 12:00 PM
Room: Room 381 A
Main Author
Brian Rohrback - Infometrix
- Scott Ramos - Infometrix
Abstract:
In applications like simulated distillation, multiple instruments can run the same method but slight differences in column and flow conditions make chromatograms not match the time axis from instrument to instrument. Normally, this would require separate calibrations or even slightly separate methods for each instrument. With chemometric alignment, these minor variations can be compensated for and identical methods be used, potentially even skipping the calibration step. The idea is very powerful: that a small amount of software can be added to a chromatograph and have that addition open a true Plug-and-Play capability for the instrument/application. Ostensibly, a company could keep a cold spare chromatograph in inventory. When a process or lab unit goes down for any reason, the storage unit would be placed on-line and have its data be completely comparable to all previous runs on its very first injection without ever running a calibration step. Alignment can also apply this procedure to the historical chromatographic data assembly, giving a consistent database ready to be mined. Of course, this conclusion holds for situations where the column and the method conditions are very similar. But if this is the case, it may be possible to think of a chromatograph with the same supply and repair mindset more often reserved for temperature and flow sensors.
