Presentation Profile
Rapid, Green, At-Line Approach to the Determination of Hydroxyl Number in Polyols
Currently Scheduled: 1/18/2018 - 2:00 PM - 2:30 PM
Room: Room 381 B
Main Author
Dr. Linda Kidder Product Manager - Shimadzu Scientific Instruments, Inc.
Abstract:
The number of hydroxyl groups on a polyol, referred to as the hydroxyl number, is a critical quality attribute (CQA) in the manufacture of flexible polyurethane and other specialty polymers. As the physical properties of the final polyurethane product depend upon the number of urethane linkages formed via these reactive hydroxyl groups, the determination of the hydroxyl number is a key QA step in the manufacturing process. The current industry standard procedure is a laboratory-based titration method using hazardous chemicals, not ideal for testing in process manufacturing where rapid determination is sought. Here, we demonstrate a spectroscopic approach using FT-NIR with Partial Least Square (PLS) regression for accurate and rapid determination of hydroxyl number in polyols. This spectroscopic approach requires no reagents or solvents, uses disposable sampling cuvettes, generates results in seconds rather than minutes (or hours) and can be place at-line. Data will be presented that highlight this approach, and a discussion of method development will be included.
